ABSTRACT
Since the outbreak of COVID-19, severe acute respiratory syndrome coronavirus 2 genome is still mutating, forming a variety of variants with strong transmission capacity, causing the spread of the epidemic worldwide, posing a serious threat to people's physical and mental health, and posing a major challenge to global public health. Omicron remains the main variant in several outbreaks worldwide, accounting for about 99% of the global genetic sequence. Recently, the World Health Organization announced that the subvariant of Omicron BA.5 has been found in more than 100 countries and regions around the world, causing the global epidemic rebound. However, there are few studies on the subvariant BA.5. This article reviews the latest research progress in epidemiology, infectivity, pathogenicity, vaccine and monoclonal antibody protection against Omicron subvariant BA.5, in order to provide reference for scientific prevention and control of Omicron subvariant BA.5.
ABSTRACT
The asymptomatic and pre-symptomatic infections of coronavirus disease 2019 (COVID-19) has no perceptible clinical symptoms and signs, and it is not easy to be detected. The transmission of the virus carried by asymptomatic and pre-symptomatic patients is insidious, which brings great challenges to the control of the epidemic. Due to the length of the incubation period, some studies have failed to distinguish between asymptomatic and pre-symptomatic infections, resulting in a higher proportion of asymptomatic infections. This article reviews the latest research progress of characteristics, transmission, detection and control of asymptomatic and pre-symptomatic infection.
ABSTRACT
The global pandemic of COVID-19 has brought great harm and challenges to many countries and regions around the world. The majority of COVID-19 patients have typical clinical manifestations, but the number of asymptomatic infections is increasing as COVID-19 research continues and SARS-CoV-2 testing improves. Many asymptomatic COVID-19 patients with no obvious clinical symptoms are able to transmit the virus to others due to the presence of SARS-CoV-2 in their bodies, thus greatly accelerating the worldwide pandemic and posing great difficulty and threat to global epidemic prevention and control. Therefore, early detection and identification of asymptomatic infected persons through various testing methods are effective measures to control the COVID-19 pandemic. This article will provide a brief review of the available methods and techniques for detecting asymptomatic COVID-19 patients.
ABSTRACT
The outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) in 2019 threatens global public health. In the early stage, respiratory symptoms are the most common in patients with new coronal pneumonia, but with the spread of the disease around the world, gastrointestinal symptoms such as diarrhea, nausea and vomiting have attracted more and more attention. And some patients take diarrhea as the first symptom, which is easy to cause missed diagnosis. This paper expounds the close relationship between COVID-19 and gastrointestinal tract, and reviews the research progress of COVID-19's effect on gastrointestinal tract.
ABSTRACT
BACKGROUND: COVID-19 is novel infectious disease with an evolving understanding of its epidemiology and clinical manifestations. Severe cases developed life-threatening complications, such as respiratory failure, shock, and multiple organs dysfunction. Immunocompromised patients often present atypical presentations of viral infected diseases. CASE PRESENTATION: We report newly diagnosed HIV infections in two patients with COVID-19 in China. In our two cases, both patients with elevated IL-6 received Tocilizumab treatment, but did not present obvious therapeutic effect. CONCLUSIONS: These cases highlight possible co-detection of known immunocompromised diseases such as HIV. The two cases we reported stressed the risk of misdiagnosis, especially during the pandemic of an infectious disease and the importance of extended testing even if in immune-compromised condition the immune state may be ignored.